Monocyte/lymphocyte ratio is associated with carotid stenosis in ischemic stroke: A retrospective analysis

作者：Bo Zuo, Sha Zhu, Xue Meng, Danhua Zhao, Jun Zhang · 发表于：Brain and Behavior · 年份：2019 · DOI：10.1002/brb3.1429 · 被引用次数：32 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Cerebrovascular and Carotid Artery Diseases、Neuroinflammation and Neurodegeneration Mechanisms

BACKGROUND: Carotid artery stenosis, mainly caused by carotid atherosclerosis, is related to ischemic stroke. This study was to investigate whether monocyte/lymphocyte ratio (MLR) was associated with increased severity of carotid stenosis in patients with ischemic stroke. METHODS: A total of 395 participants with ischemic stroke were retrospectively analyzed. The severity of carotid stenosis was evaluated by ultrasound examination. Patients were divided into two groups: nonsevere stenosis group and severe stenosis group. Multivariate logistic analysis was used to evaluate risk factors. RESULTS: A significant correlation was found between MLR and the severity of carotid stenosis in patients with ischemic stroke. MLR was the independent risk factor of carotid stenosis (OR: 9.74, 95% CI: 1.16-81.54). In the ROC curves analysis, a cutoff value of 0.20 for MLR predicted the severity of carotid stenosis with a sensitivity of 80.40% and specificity of 26.40% (ROC area under the curve: 0.598, 95% CI: 0.53-0.67, p = .004). CONCLUSION: Monocyte/lymphocyte ratio plays important roles in carotid stenosis in patients with ischemic stroke and is an independent risk factor of the severity of carotid stenosis. Therefore, MLR might be considered a potential index in the diagnosis of carotid stenosis in patients with ischemic stroke.