Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization

作者：Dingquan Huang, Yanbiao Sun, Zhiming Ma, Meiyu Ke, Yong Cui, Zichen Chen, Chaofan Chen, Changyang Ji, Tuan Minh Tran, Liang Yang, Sin Man Lam, Yanhong Han, Guanghou Shui, Zhuang Wei, Shutang Tan, Kan Liao, Jiřı́ Friml, Yansong Miao, Liwen Jiang, Xu Chen · 发表于：Proceedings of the National Academy of Sciences · 年份：2019 · DOI：10.1073/pnas.1911892116 · 被引用次数：161 · 研究领域：Plant Virus Research Studies、Legume Nitrogen Fixing Symbiosis、Plant nutrient uptake and metabolism

Significance Plasmodesmata (PD) create cytoplasmic and membrane continuities between adjacent cells to facilitate cell–cell communication and virus movement. Plant cells have evolved diverse mechanisms to regulate PD plasticity against plant pathogens, including the accumulation of the defense hormone, salicylic acid (SA). However, the mechanism of how this occurs is not well understood. Here, we uncover a mechanism by which SA triggers Remorin-dependent membrane lipid nanodomain assembly, leading to enhancement of the liquid-ordered phase. The higher-ordered lipids, which are particularly enriched at PD membrane, decreased PD membrane plasticity, and thus restricted PD opening and impeded virus spreading. Our findings address a knowledge gap in plant defense mechanisms at the membrane level that rely on SA-controlled lipid order and PD closure.