Trace amine associated receptor 1 (TAAR1) expression and modulation of inflammatory cytokine production in mouse bone marrow-derived macrophages: a novel mechanism for inflammation in ulcerative colitis

作者：Katlynn Bugda Gwilt, Neva Olliffe, Rachel A. Hoffing, Gregory M. Miller · 发表于：Immunopharmacology and Immunotoxicology · 年份：2019 · DOI：10.1080/08923973.2019.1672178 · 被引用次数：22 · 研究领域：Immune Cell Function and Interaction、Adenosine and Purinergic Signaling、Immune cells in cancer

Katlynn Bugda Gwiltab* , Neva Olliffecd, Rachel A. Hoffingc & Gregory M. Millerabea Department of Pharmaceutical Sciences, Northeastern University, Boston, MA, USA; b Center for Drug Discovery, Northeastern University, Boston, MA, USA; c Department of Biology, Northeastern University, Boston, MA, USA; d Honors Program, Northeastern University, Boston, MA, USA; e Department of Chemical Engineering, Northeastern University, Boston, MA, USASupplemental data for this article can be accessed here.CONTACT Katlynn Bugda Gwilt gwilt.k@husky.neu.edu Boston Children’s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, USAAbstractContext: Tissue resident macrophages and peripherally infiltrating macrophages play a prominent role in maintaining homeostasis in the gastrointestinal tract (GIT), though aberrant activation is implicated in inflammatory conditions, including ulcerative colitis (UC). Recent metabolomic studies indicate that tyramine (TYR) is elevated in the stool of patients with UC. TYR activates the mammalian trace amine associated receptor 1 (TAAR1). Our previous work identified TAAR1 expression in mixed populations of immune cells, whereas a limited number of other studies have identified TAAR1-dependent effects in cytokine secretion and gene expression in T-cells and B-cells.Objective: To investigate whether TAAR1 may serve as a novel target for an anti-inflammatory therapeutic in UC, we explored TAAR1 expression in mouse bone marrow-derived macrophages (B...