Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes

作者：Dena Zeraatkar, Bradley C. Johnston, Jessica Julia Bartoszko, Kevin J. Cheung, Małgorzata Maria Bała, Claudia Valli, Montserrat Rabassa, Daegan Sit, Kirolos Milio, Behnam Sadeghirad, Arnav Agarwal, Adriana M. Zea, Yung Lee, Mi Ah Han, Robin W.M. Vernooij, Pablo Alonso‐Coello, Gordon Henry Guyatt, Regina El Dib · 发表于：Annals of Internal Medicine · 年份：2019 · DOI：10.7326/m19-0622 · 被引用次数：133 · 研究领域：Nutritional Studies and Diet、Agriculture Sustainability and Environmental Impact、Meat and Animal Product Quality

This article has been corrected. The original version (PDF) is appended to this article as a Supplement. Background: Few randomized trials have evaluated the effect of reducing red meat intake on clinically important outcomes. Purpose: To summarize the effect of lower versus higher red meat intake on the incidence of cardiometabolic and cancer outcomes in adults. Data Sources: EMBASE, CENTRAL, CINAHL, Web of Science, and ProQuest from inception to July 2018 and MEDLINE from inception to April 2019, without language restrictions. Study Selection: Randomized trials (published in any language) comparing diets lower in red meat with diets higher in red meat that differed by a gradient of at least 1 serving per week for 6 months or more. Data Extraction: Teams of 2 reviewers independently extracted data and assessed the risk of bias and the certainty of the evidence. Data Synthesis: Of 12 eligible trials, a single trial enrolling 48 835 women provided the most credible, though still low-certainty, evidence that diets lower in red meat may have little or no effect on all-cause mortality (hazard ratio [HR], 0.99 [95% CI, 0.95 to 1.03]), cardiovascular mortality (HR, 0.98 [CI, 0.91 to 1.06]), and cardiovascular disease (HR, 0.99 [CI, 0.94 to 1.05]). That trial also provided low- to very-low-certainty evidence that diets lower in red meat may have little or no effect on total cancer mortality (HR, 0.95 [CI, 0.89 to 1.01]) and the incidence of cancer, including colorectal cancer (HR, 1...