Uncovering cortical activations of discourse comprehension and their overlaps with common large-scale neural networks

作者：Xiaohong Yang, Hui‐Jie Li, Nan Lin, Xiuping Zhang, Yinshan Wang, Ying Zhang, Qian Zhang, Xi‐Nian Zuo, Yufang Yang · 发表于：NeuroImage · 年份：2019 · DOI：10.1016/j.neuroimage.2019.116200 · 被引用次数：39 · 研究领域：Neurobiology of Language and Bilingualism、Functional Brain Connectivity Studies、Action Observation and Synchronization

We conducted a meta-analysis of 78 task-based functional magnetic resonance imaging (fMRI) studies (1976 total participants) to reveal underlying brain activations and their overlap with large-scale neural networks in the brain during general discourse comprehension and its sub-processes. We found that discourse comprehension involved a neural system consisting of widely distributed brain regions that comprised not only the bilateral perisylvian language zones, but also regions in the superior and medial frontal cortex and the medial temporal lobe. Moreover, this neural system can be categorized into several sub-systems representing various sub-processes of discourse comprehension, with the left inferior frontal gyrus and middle temporal gyrus serving as core regions across all sub-processes. At a large-scale network level, we found that discourse comprehension relied most heavily on the default network, particularly on its dorsal medial subsystem. The pattern associated with large-scale network cooperation varied according to the respective sub-processes required. Our results reveal the functional dissociation within the discourse comprehension neural system and highlight the flexible involvements of large-scale networks.