Synthetic Ion Channels

作者：Ulrich Koert, Lo'ay Ahmed Al-Momani, Jochen R. Pfeifer · 发表于：Synthesis · 年份：2004 · DOI：10.1055/s-2004-822385 · 被引用次数：69 · 研究领域：Molecular Sensors and Ion Detection、Analytical Chemistry and Sensors、Mass Spectrometry Techniques and Applications

Progress in the synthesis of membrane-bound ion channels is reviewed. Important results from several groups are highlighted and contributions from the authors’ group are summarized. Topics covered include synthetic approaches towards oligo-THF amino acids, oligopyrrolidines and gramicidin hybrid channels. Points of interest are the importance of self-assembly systems, the functional analysis (ion selectivity, gating, asymmetric insertion and asymmetric function) and the structural characterization of the channel.