An aminophosphonate ester ligand-containing platinum( ii ) complex induces potent immunogenic cell death in vitro and elicits effective anti-tumour immune responses in vivo

作者：Ke-Bin Huang, Feng-Yang Wang, Hai-Wen Feng, Hejiang Luo, Long Yan, Taotao Zou, Albert S. C. Chan, Rong Liu, Hua‐Hong Zou, Zhen‐Feng Chen, Yan‐Cheng Liu, You‐Nian Liu, Hong Liang · 发表于：Chemical Communications · 年份：2019 · DOI：10.1039/c9cc06563f · 被引用次数：69 · 研究领域：Metal complexes synthesis and properties、Synthesis and Biological Evaluation、Click Chemistry and Applications

A platinum(ii) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) in association with potent ER stress and reactive oxygen species generation, followed by the activation of damage-associated molecular pattern signals and immune responses. Importantly, the Pt complex exhibits potent anti-tumour activities in two independent mouse models via an immunogenic cell death pathway.