Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice

作者：Panpan Xian, Yue Hei, Rui Wang, Tian Wang, Junle Yang, Jianying Li, Zhengli Di, Zhiqin Liu, Andrius Baskys, Weiping Liu, Shengxi Wu, Qianfa Long · 发表于：Theranostics · 年份：2019 · DOI：10.7150/thno.33872 · 被引用次数：402 · 研究领域：Extracellular vesicles in disease、MicroRNA in disease regulation、Neuroinflammation and Neurodegeneration Mechanisms

: Our results show that MSC-Exo ameliorate inflammation-induced astrocyte alterations and that the Nrf2-NF-κB signaling pathway is involved in regulating astrocyte activation in mice. These data suggest the promising potential of MSC-Exo as a nanotherapeutic agent for the treatment of neurological diseases with hippocampal astrocyte alterations.