Complement component 4 variations may influence psychopathology risk in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

作者：Lao Q, Jardin MD, Rahul Jayakrishnan, Markus Ernst, Merke DP · 发表于：Yearbook of pediatric endocrinology · 年份：2019 · DOI：10.1530/ey.16.8.7 · 被引用次数：1 · 研究领域：Sexual Differentiation and Disorders、Hormonal and reproductive studies、Metabolism and Genetic Disorders

Patients with Congenital adrenal hyperplasia (CAH) suffer from multiple comorbidities, including mental illness. Studies that investigated the prevalence of psychiatric disorders in patients with CAH showed that any psychiatric diagnosis were more common in CAH subjects compared with population controls. In particular, the risk of alcohol misuse was increased in females with CAH compared with controls, and appeared most common among the girls and women with the most severe null genotype. The risk of stress and adjustment disorders was doubled compared with female population controls. Furthermore, suicidality, other psychiatric disorders (excluding suicidality), and alcohol misuse were increased in males with CAH compared with controls. There was no increased risk for any neurodevelopmental disorder.