Allostatic Load as a Biological Substrate to Intrinsic Capacity: A Secondary Analysis of CRELES

作者：Luis Miguel Gutiérrez‐Robledo, Rosa Estela García-Chanes, Mario Ulises Pérez‐Zepeda · 发表于：The journal of nutrition health & aging · 年份：2019 · DOI：10.1007/s12603-019-1251-5 · 被引用次数：81 · 研究领域：Nutrition and Health in Aging、Frailty in Older Adults、Genetics, Aging, and Longevity in Model Organisms

OBJECTIVES: Intrinsic capacity (IC) is one of the latest views of positive aging. In its current status lacks a biological substrate amenable to be intervened. The aim of this study was to determine the association of allostatic load (AL) with IC. DESIGN: We present a cross-sectional analysis of the Costa Rican Longevity and Healthy Aging Study. SETTING: This report is from a representative sample of Costa Rican older adults; one of the countries that integrate the Central America region. PARTICIPANTS: 2,827, 60-year or older community-dwelling individuals. METHODS: An IC index was gathered and validated, including different domains: cognitive, psychological, sensory, vitality and locomotion. AL was integrated with: blood pressure, abdominal obesity, body mass index, HDL-cholesterol, glycosylated hemoglobin, DHEAS, cortisol, epinephrine and norepinephrine. AL was grouped in three categories according to the number of abnormal biomarkers (0-1, 2-3 and ≥4). Chronic diseases, socioeconomic level, sex and age were the adjusting variables. Ordinal logistic regression models were estimated in order to test the strength of the association. RESULTS: From a total sample of 1,888 individuals, 51% (n=962) were women, 36.4% were in the 60-69 age category. The mean score of the IC index was of 6.6 (±2.2). Odds ratio (OR) of the adjusted models were significant for the group of those with 2-3 abnormal biomarkers of AL (OR 0.67, p=0.007) and also for those with ≥4 (OR 0.56, p=0.002), when c...