Cohort Profile: The Canadian Longitudinal Study on Aging (CLSA)

作者：Parminder S. Raina, Christina M. Wolfson, Susan Kirkland, Lauren E. Griffith, Cynthia M. Balion, Benoît Cossette, Isabelle J. Dionne, Scott M. Hofer, David B. Hogan, Edwin R. van den Heuvel, Teresa Y L Liu-Ambrose, Verena H. Menec, Gerald J. Mugford, Christopher C. Patterson, Hélène Payette, Brent J. Richards, Harry S. Shannon, Debra J. Sheets, Vanessa Taler, Mary Elizabeth Thompson, Holly Anna Tuokko, Andrew Wister, Changbao Wu, Lynne Young · 发表于：International Journal of Epidemiology · 年份：2019 · DOI：10.1093/ije/dyz173 · 被引用次数：567 · 研究领域：Health disparities and outcomes、Global Health Care Issues、Migration, Aging, and Tourism Studies

The Canadian Longitudinal Study on Aging (CLSA) was established to understand and address the needs of an aging population.1–3 Overall aims are to examine aging as a dynamic process; to investigate the inter-relationship among intrinsic and extrinsic factors from mid-life to older age; and to capture the transitions, trajectories and profiles of aging.4 A central objective in creating the CLSA was to provide national infrastructure and build capacity for state-of-the-art, interdisciplinary, population-based research and evidence-based decision-making.5,6 The CLSA was designed to be a national, longitudinal research platform that includes participants from all 10 Canadian provinces, and collects comprehensive data and biological samples that will support a wide variety of aging-related research questions.3 The cohort of 51 338 participants, aged 45–85 years at enrolment, is composed of two complementary cohorts that may be studied separately or together: (1) the Tracking cohort of 21 241 participants randomly selected from within all 10 provinces who are interviewed by telephone, and (2) the Comprehensive cohort of 30 097 participants randomly selected from within 25–50 km of 11 data collection sites (DCSs) (in seven provinces) who are interviewed in person, take part in in-depth physical assessments at DCSs, and provide blood and urine samples. To support research that integrates the two cohorts, a common set of questionnaire information is being collected for both the Tracki...