Comparison of the Full Distribution of Fitness Effects of New Amino Acid Mutations Across Great Apes

作者：David Castellano, Moisès Coll Macià, Paula Tataru, Thomas Bataillon, Kasper Munch · 发表于：Genetics · 年份：2019 · DOI：10.1534/genetics.119.302494 · 被引用次数：69 · 研究领域：Evolution and Genetic Dynamics、Vector-borne infectious diseases、Insect and Pesticide Research

Abstract Castellano et al. provide the first comparison of the full distribution of fitness effects (including deleterious, neutral but also beneficial mutations) in the great apes. The authors investigate which aspects of the full DFE are likely... The distribution of fitness effects (DFE) is central to many questions in evolutionary biology. However, little is known about the differences in DFE between closely related species. We use >9000 coding genes orthologous one-to-one across great apes, gibbons, and macaques to assess the stability of the DFE across great apes. We use the unfolded site frequency spectrum of polymorphic mutations (n = 8 haploid chromosomes per population) to estimate the DFE. We find that the shape of the deleterious DFE is strikingly similar across great apes. We confirm that effective population size (Ne) is a strong predictor of the strength of negative selection, consistent with the nearly neutral theory. However, we also find that the strength of negative selection varies more than expected given the differences in Ne between species. Across species, mean fitness effects of new deleterious mutations covaries with Ne, consistent with positive epistasis among deleterious mutations. We find that the strength of negative selection for the smallest populations, bonobos and western chimpanzees, is higher than expected given their Ne. This may result from a more efficient purging of strongly deleterious recessive variants in these populations. Fo...