Oxidase‐Like Fe‐N‐C Single‐Atom Nanozymes for the Detection of Acetylcholinesterase Activity

作者：Yu Wu, Lei Jiao, Xin Luo, Weiqing Xu, Xiaoqian Wei, Hengjia Wang, Hongye Yan, Wenling Gu, Bo Z. Xu, Dan Du, Yuehe Lin, Chengzhou Zhu · 发表于：Small · 年份：2019 · DOI：10.1002/smll.201903108 · 被引用次数：320 · 研究领域：Advanced Nanomaterials in Catalysis、Nanocluster Synthesis and Applications、Electrochemical sensors and biosensors

Abstract Single‐atom catalysts (SACs) have attracted extensive attention in the catalysis field because of their remarkable catalytic activity, gratifying stability, excellent selectivity, and 100% atom utilization. With atomically dispersed metal active sites, Fe‐N‐C SACs can mimic oxidase by activating O2 into reactive oxygen species, O2−• radicals. Taking advantages of this property, single‐atom nanozymes (SAzymes) can become a great impetus to develop novel biosensors. Herein, the performance of Fe‐N‐C SACs as oxidase‐like nanozymes is explored. Besides, the Fe‐N‐C SAzymes are applied in biosensor areas to evaluate the activity of acetylcholinesterase based on the inhibition toward nanozyme activity by thiols. Moreover, this SAzymes‐based biosensor is further used for monitoring the amounts of organophosphorus compounds.