Antioxidant and Hypolipidemic Activities of Acid-Depolymerised Exopolysaccharides by Termitomyces albuminosus

作者：Huajie Zhao, Xiuxiu Wang, Xinchao Liu, Jianjun Zhang, Luzhang Wan, Le Jia · 发表于：Oxidative Medicine and Cellular Longevity · 年份：2019 · DOI：10.1155/2019/8915272 · 被引用次数：15 · 研究领域：Seaweed-derived Bioactive Compounds、Polysaccharides Composition and Applications、Microbial Metabolites in Food Biotechnology

The acid-depolymerised exopolysaccharides (ADES) of Termitomyces albuminosus were obtained, and the major fraction of ADES1 was isolated and purified by DEAE-52 cellulose anion-exchange column chromatography. Physicochemical characterizations showed that ADES1 was an α - and a β -configuration with the molecular weight of 2.43 kDa, containing (1→3, 4)-linked-Glc p , (1→4)-linked-D-Glc p , (1→3)-linked-D-Xyl p , (1→4)-linked-D-Man p , T-Glc p , (1→6)-linked-D-Gal p , and (1→4)-linked-L-Ara p . The in vivo assays showed that ADES1 could reduce lipid levels in the serum and liver, decrease serum enzyme activities, and improve antioxidant enzyme activities and p-AMPK α expressions in hyperlipidemic mice, which were also confirmed by histopathological observations. These data indicated that ADES1 might be considered as a novel substance to treat and prevent hyperlipidemia and as a hepatoprotective agent.