N 6 -methyladenosine RNA modification–mediated cellular metabolism rewiring inhibits viral replication

作者：Yang Liu, Yuling You, Zhike Lu, Yang Jiang, Panpan Li, Lun Liu, Henan Xu, Yamei Niu, Xuetao Cao · 发表于：Science · 年份：2019 · DOI：10.1126/science.aax4468 · 被引用次数：221 · 研究领域：RNA modifications and cancer、Epigenetics and DNA Methylation、Cancer-related molecular mechanisms research

RNA modification meets immune metabolism N 6 -methyladenosine (m 6 A) RNA modification regulates various cellular functions. Liu et al. found that host cells impair RNA m 6 A demethylase activity after viral infection, leading to increased m 6 A and reduced stability of α-ketoglutarate dehydrogenase (OGDH) mRNA. As a result, reduced OGDH decreases the generation of itaconate, thereby inhibiting viral replication. The authors explore the function of OGDH and itaconate in viral infection, provide insights into m 6 A RNA modification and metabolic reprogramming in modulating virus-host interaction, and suggest potential therapeutic targets for the control of viral infection. Science , this issue p. 1171