Nematicidal metabolites from endophytic fungus Chaetomium globosum YSC5

作者：Babar Khan, Wei Yan, Shan Wei, Zhiyang Wang, Shuangshuang Zhao, Lingling Cao, Nasir Ahmed Rajput, Yonghao Ye · 发表于：FEMS Microbiology Letters · 年份：2019 · DOI：10.1093/femsle/fnz169 · 被引用次数：53 · 研究领域：Nematode management and characterization studies、Entomopathogenic Microorganisms in Pest Control、Plant Pathogens and Fungal Diseases

Management of nematodes is a very hectic job due to a highly diverse group of organisms. To find lead compounds for new nematicide development, five metabolites (1-5) were isolated from the culture broth of Chaetomium globosum YSC5 and tested for nematicidal activities against the second stage juveniles (J2s) of Meloidogyne javanica. The results revealed that chaetoglobosin A (1), chaetoglobosin B (2) and flavipin (3) exhibited strong adverse effects (91.6, 83.8 and 87.4%, respectively) on J2 mortality at 200 μg/mL with LC50 values of 88.4, 107.7 and 99.2 μg/mL after 72 h, respectively, while 3-methoxyepicoccone (4) and 4,5,6-trihydroxy-7-methylphthalide (5) showed moderate effects (78.0 and 75.5%, respectively) with LC50 values of 124.0 and 131.6 μg/mL, respectively. Furthermore, in pot assay compounds 1 and 2 appeared to be promising metabolites at 200 μg/mL that significantly reduced nematode reproduction and showed a positive influence on plant growth. Our findings could be helpful for development of new potential bio-based pesticides for integrated management of plant-parasitic nematode.