The association of body mass index, weight gain and central obesity with activity-related breathlessness: the Swedish Cardiopulmonary Bioimage Study

作者：Magnus Pär Ekström, Anders Blomberg, Göran Bergström, John Brandberg, Kenneth Caidahl, Gunnar Engström, Jan Engvall, Maria J. Eriksson, Klas Gränsbo, Tomas Hansen, Tomas Jernberg, Lars T. Nilsson, Ulf Nilsson, Anna‐Carin Olin, Hans Lennart Persson, Annika Rosengren, Martin Sandelin, Magnus Sköld, Johan Sundström, Eva Swahn, Stefan Söderberg, Hanan Tanash, Kjell Torén, Carl Johan Östgren, Eva Lindberg · 发表于：Thorax · 年份：2019 · DOI：10.1136/thoraxjnl-2019-213349 · 被引用次数：34 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Delphi Technique in Research、Obstructive Sleep Apnea Research

Introduction Breathlessness is common in the population, especially in women and associated with adverse health outcomes. Obesity (body mass index (BMI) >30 kg/m2) is rapidly increasing globally and its impact on breathlessness is unclear. Methods This population-based study aimed primarily to evaluate the association of current BMI and self-reported change in BMI since age 20 with breathlessness (modified Research Council score ≥1) in the middle-aged population. Secondary aims were to evaluate factors that contribute to breathlessness in obesity, including the interaction with spirometric lung volume and sex. Results We included 13 437 individuals; mean age 57.5 years; 52.5% women; mean BMI 26.8 (SD 4.3); mean BMI increase since age 20 was 5.0 kg/m2; and 1283 (9.6%) reported breathlessness. Obesity was strongly associated with increased breathlessness, OR 3.54 (95% CI, 3.03 to 4.13) independent of age, sex, smoking, airflow obstruction, exercise level and the presence of comorbidities. The association between BMI and breathlessness was modified by lung volume; the increase in breathlessness prevalence with higher BMI was steeper for individuals with lower forced vital capacity (FVC). The higher breathlessness prevalence in obese women than men (27.4% vs 12.5%; p<0.001) was related to their lower FVC. Irrespective of current BMI and confounders, individuals who had increased in BMI since age 20 had more breathlessness. Conclusion Breathlessness is independently associated wit...