Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity

作者：Bryan A. Johnson, Adam Hage, Birte Kalveram, Megan C. Mears, Jessica A. Plante, Sergio E. Rodriguez, Zhixia Ding, Xuemei Luo, Dennis A. Bente, Shelton S. Bradrick, Alexander N. Freiberg, Vsevolod L. Popov, Ricardo Rajsbaum, Shannan L. Rossi, William K. Russell, Vineet D. Menachery · 发表于：Journal of Virology · 年份：2019 · DOI：10.1128/jvi.01282-19 · 被引用次数：65 · 研究领域：Viral gastroenteritis research and epidemiology、Viral Infections and Outbreaks Research、SARS-CoV-2 and COVID-19 Research

In this article, we consider a role for bacteria in shaping coronavirus infection. Taking cues from studies of enteric viruses, we initially investigated how bacterial surface components might improve CoV infection. Instead, we found that peptidoglycan-associated surfactin is a potent viricidal compound that disrupts virion integrity with broad activity against enveloped viruses. Our results indicate that interactions with commensal bacterial may improve or disrupt viral infections, highlighting the importance of understanding these microbial interactions and their implications for viral pathogenesis and treatment.