Delineating functional segregations of the human middle temporal gyrus with resting‐state functional connectivity and coactivation patterns

作者：Jinping Xu, Hanqing Lyu, Tian Li, Ziyun Xu, Xianjun Fu, Fucang Jia, Jiaojian Wang, Qingmao Hu · 发表于：Human Brain Mapping · 年份：2019 · DOI：10.1002/hbm.24763 · 被引用次数：127 · 研究领域：Functional Brain Connectivity Studies、Neural dynamics and brain function、Neuroscience and Music Perception

Although the middle temporal gyrus (MTG) has been parcellated into subregions with distinguished anatomical connectivity patterns, whether the structural topography of MTG can inform functional segregations of this area remains largely unknown. Accumulating evidence suggests that the brain's underlying organization and function can be directly and effectively delineated with resting-state functional connectivity (RSFC) by identifying putative functional boundaries between cortical areas. Here, RSFC profiles were used to explore functional segregations of the MTG and defined four subregions from anterior to posterior in two independent datasets, which showed a similar pattern with MTG parcellation scheme obtained using anatomical connectivity. The functional segregations of MTG were further supported by whole brain RSFC, coactivation, and specific RFSC, and coactivation mapping. Furthermore, the fingerprint with predefined 10 networks and functional characterizations of each subregion using meta-analysis also identified functional distinction between subregions. The specific connectivity analysis and functional characterization indicated that the bilateral most anterior subregions mainly participated in social cognition and semantic processing; the ventral middle subregions were involved in social cognition in left hemisphere and auditory processing in right hemisphere; the bilateral ventro-posterior subregions participated in action observation, whereas the left subregion was...