The 2019 WHO classification of tumours of the digestive system

作者：Irıs D. Nagtegaal, Robert D. Odze, David S. Klimstra, Valérie Paradis, Massimo Rugge, Peter Schirmacher, Kay Washington, Fátima Carneiro, Ian A. Cree, the WHO Classification of Tumours Editorial Board · 发表于：Histopathology · 年份：2019 · DOI：10.1111/his.13975 · 被引用次数：4216 · 研究领域：Pancreatic and Hepatic Oncology Research、Cancer Genomics and Diagnostics、Cholangiocarcinoma and Gallbladder Cancer Studies

The WHO classification of digestive system tumours presented in the first volume of the WHO classification of tumours series, 5th edition, reflects important advancements in our understanding of tumours of the digestive system (Table 1). For the first time, certain tumour types are defined as much by their molecular phenotype as their histological characteristics; however, in most instances histopathological classification remains the gold standard for diagnosis. The WHO classification of tumours series is designed to be used worldwide, including those settings where a lack of tissue samples or of specific technical facilities limits the pathologist's ability to rely on molecular testing. Since the publication of the 4th-edition digestive system tumours volume in 2010,1 there have been important developments in our understanding of the aetiology and pathogenesis of many tumours. However, the extent to which this new information has altered clinical practice has been quite variable. For some of the tumours described in this volume there is little molecular pathology in clinical use, despite the fact that we now have a more detailed understanding of their molecular pathogenesis. A tumour's molecular pathology, as defined for the purposes of this publication, concerns the molecular markers that are relevant to the tumour's diagnosis, biological behaviour, outcome and treatment, rather than its molecular pathogenesis. However, the role of molecular pathology is expanding; for som...