Dynamic Functional Connectivity Within the Fronto-Limbic Network Induced by Intermittent Theta-Burst Stimulation: A Pilot Study

作者：Yingying Tang, Xiong Jiao, Jijun Wang, Jijun Wang, Tianyuan Zhu, Jie Zhou, Zhenying Qian, Tianhong Zhang, HuiRu Cui, Hui Li, XiaoChen Tang, Lihua Xu, Ling Zhang, YanYan Wei, Jianhua Sheng, Liu Liu, Jijun Wang, Jijun Wang · 发表于：Frontiers in Neuroscience · 年份：2019 · DOI：10.3389/fnins.2019.00944 · 被引用次数：37 · 研究领域：Transcranial Magnetic Stimulation Studies、Functional Brain Connectivity Studies、Spatial Neglect and Hemispheric Dysfunction

Purpose: The utility of transcranial magnetic stimulation (TMS) is growing rapidly in both neurocognitive studies and clinical applications in the decades. However, it remains unclear how the responses of the stimulated site and the site-related functional network to the external TMS manipulation dynamically change over time. Methods: A multi-session combing TMS-fMRI experiment was conducted to explore the spatiotemporal effects of TMS within the fronto-hippocampal network. Ten healthy volunteers were modulated by intermittent theta-burst stimulation (iTBS) at a precise site within the left dorsolateral prefrontal cortex (DLPFC, MNI coordinate [-44 36 20]), navigated by individual structural MRI image. Three-session resting-state fMRI images were acquired before iTBS (TP1), immediately after iTBS (TP2) and 15 minutes after iTBS (TP3) for each participant. Twelve regions of interests (ROIs) within fronto-hippocampal network were chosen including the bilateral superior frontal gyrus (SFG), bilateral middle frontal gyrus (MidFG), bilateral triangularis (IFG_tri) and pars opercularis (IFG_oper) parts of inferior frontal gyrus, medial frontal cortex (MedFC), anterior cingulate gyrus (AC) and bilateral hippocampus. Voxel-wise fractional amplitude of low-frequency fluctuation (fALFF) and ROI-to-ROI functional connectivity (FC) were compared among TP1, TP2 and TP3. Results: The immediate iTBS effect was observed at the stimulated site. FC was decreased between the left MidFC / SFG an...