Prevalence of hyperfiltration among US youth/young adults with overweight and obesity: A population‐based association study

作者：Christy B. Turer, Michel Baum, Laurence Dubourg, Luciano da Silva Selistre, Asheley Cockrell Skinner · 发表于：Obesity Science & Practice · 年份：2019 · DOI：10.1002/osp4.365 · 被引用次数：29 · 研究领域：Chronic Kidney Disease and Diabetes、Dialysis and Renal Disease Management、Bariatric Surgery and Outcomes

Summary Objective Determine prevalence of hyperfiltration (high estimated glomerular filtration rate " e GFR" >95th percentile for age/sex) among youth and association with BMI classification. Methods With the use of 1999 to 2016 National Health and Nutrition Examination Survey data from 12‐ to 29‐year‐olds, data for serum creatinine and thresholds for high e GFR were normed using a metabolically healthy subsample (no albuminuria, healthy weights, normal blood pressures, blood glucoses, lipids, and liver enzymes). Logistic regression examined the association of BMI classification (healthy weight, overweight, and obesity classes 1‐3) with hyperfiltration ( e GFR > 95th percentile for age/sex), adjusted for diabetes and other covariates. Results Of 12‐ to 29‐year‐olds ( N = 18 698), 27.4% ( n = 5493) met criteria for entry into the "healthy subsample" and contributed data to derive normative values for serum creatinine/hyperfiltration thresholds. In the full sample, hyperfiltration prevalence in 12‐ to 29‐year‐olds classified as healthy‐weight, overweight, and obesity classes 1 to 3 was 4.9%, 4.7%, 6.5%, 8.7%, and 11.8%, respectively ( P < .001). In multivariable analysis, obesity classes 2 and 3 were associated with greater likelihood of hyperfiltration (adjusted ORs for class 2: 1.5, 95% CI, 1.1‐2.1; and for class 3, 2.1, 95% CI, 1.5‐2.9). Diabetes also was associated with hyperfiltration (AOR, 4.0; 95% CI, 2.2‐7.4). Conclusion Obesity classes 2 to 3 are associated w...