Asymmetric Difluoromethylthiolation of Carbon Nucleophiles with Optically Pure Difluoromethylthiolating Reagents Derived from Camphorsultam

作者：He Zhang, Xiaolong Wan, Qilong Shen · 发表于：Chinese Journal of Chemistry · 年份：2019 · DOI：10.1002/cjoc.201900298 · 被引用次数：35 · 研究领域：Fluorine in Organic Chemistry、Synthesis and Reactions of Organic Compounds、Cyclopropane Reaction Mechanisms

Summary of main observation and conclusion The invention of a family of optically pure electrophilic difluoromethylthiolating reagents 9a – c based on the camphorsultam skeleton was described. These reagents reacted with a variety of soft carbon nucleophiles such as oxazolone, oxindole, benzolactone and β‐ketoester in good to excellent enantioselectivities.