A Chemical Photo‐Oxidation of 5‐Methyl Cytidines

作者：Xiaoyang Jin, Rui‐Li Wang, Li‐Jun Xie, De‐Long Kong, Li Liu, Liang Cheng · 发表于：Advanced Synthesis & Catalysis · 年份：2019 · DOI：10.1002/adsc.201900811 · 被引用次数：28 · 研究领域：RNA modifications and cancer、Epigenetics and DNA Methylation、Cytomegalovirus and herpesvirus research

Abstract A new approach for the oxidation of 5‐methyl cytidine modification in nucleic acids to 5‐formyl cytidine is reported. This method displays excellent chemo‐/bio‐ selectivity, from which the methyl group in cytidine nucleosides could be selectively oxidized to biologically important formyl functionality without interfering with other cellular biomolecules. magnified image