One Stone with Two Birds: Functional Gold Nanostar for Targeted Combination Therapy of Drug-Resistant Staphylococcus aureus Infection

作者：Huajuan Wang, Zhiyong Song, Shuojun Li, Yang Wu, Heyou Han · 发表于：ACS Applied Materials & Interfaces · 年份：2019 · DOI：10.1021/acsami.9b09824 · 被引用次数：80 · 研究领域：Nanoplatforms for cancer theranostics、Antimicrobial Peptides and Activities、Gold and Silver Nanoparticles Synthesis and Applications

The development of new antibacterial agents to deal with the emergence and spread of antibiotic resistance in Gram-positive bacterial pathogens has become an increasing problem. Here, a new strategy is developed for the effective targeting and killing of Gram-positive bacteria based on vancomycin (Van)-modified gold nanostars (AuNSs). Our work has demonstrated that the Van-modified AuNSs ( [email protected] ) can not only selectively recognize methicillin-resistant Staphylococcus aureus ( MRSA) but also kill MRSA under near-infrared laser irradiation in vitro. Additionally, [email protected] shows satisfactory biocompatibility and antibacterial activity in treating bacterial infection in vivo. The attractive trait of [email protected] is attributed to the physical effect of its antibacterial activity, with less potential for resistance development. The aforementioned advantages indicate the potential of [email protected] as a photothermal antibacterial agent for effectively combating Gram-positive bacteria in the field of health care.