Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation

作者：Ann-Katrin Hopp, Patrick Grüter, Michael O. Hottiger · 发表于：Cells · 年份：2019 · DOI：10.3390/cells8080890 · 被引用次数：113 · 研究领域：Sirtuins and Resveratrol in Medicine、PARP inhibition in cancer therapy、Calcium signaling and nucleotide metabolism

Cells constantly adapt their metabolic pathways to meet their energy needs and respond to nutrient availability. During the last two decades, it has become increasingly clear that NAD+, a coenzyme in redox reactions, also mediates several ubiquitous cell signaling processes. Protein ADP-ribosylation is a post-translational modification that uses NAD+ as a substrate and is best known as part of the genotoxic stress response. However, there is increasing evidence that NAD+-dependent ADP-ribosylation regulates other cellular processes, including metabolic pathways. In this review, we will describe the compartmentalized regulation of NAD+ biosynthesis, consumption, and regeneration with a particular focus on the role of ADP-ribosylation in the regulation of glucose metabolism in different cellular compartments.