Overexpression of MAGT1 is associated with aggressiveness and poor prognosis of colorectal cancer

作者：Kehong Zheng, Qianqiong Yang, Lang Xie, Zhenghua Qiu, Yongsheng Huang, Yongwei Lin, Lingjing Tu, Chunhui Cui · 发表于：Oncology Letters · 年份：2019 · DOI：10.3892/ol.2019.10710 · 被引用次数：22 · 研究领域：Magnesium in Health and Disease、Parathyroid Disorders and Treatments、Plant Micronutrient Interactions and Effects

Tumor metastasis and anticancer drug resistance are the major causes of mortality in patients with colorectal cancer (CRC). Due to the limitations of conventional biomarkers, it is urgent to identify novel and valid biomarkers to predict the progression and prognosis of CRC. Reverse transcription-quantitative polymerase chain reaction and western blotting were used to detect MAGT1 expression in CRC clinical samples or cell lines. Bioinformatics analysis was used to investigate the association between MAGT1 alteration and clinicopathological features of patients with CRC. The present study revealed that the transcription levels of magnesium transporter 1 (MAGT1) were significantly increased in CRC tissues compared with matched adjacent normal tissues. Overexpression of MAGT1 was associated with advanced tumor stage, N and M classification. In addition, for patients who underwent chemotherapy, patients in the MAGT1-low expression group exhibited a longer overall survival (OS) time than patients in the high-expression group. Patients with CRC treated with chemotherapy had a longer OS time than those treated without chemotherapy in the MAGT1-low expression group but not in the MAGT1-high expression group. Furthermore, MAGT1 was a valid but not an independent prognostic factor for CRC. Therefore, the present study highlighted that MAGT1 may serve as a valid biomarker for predicting the development, progression and poor prognosis of CRC.