Isavuconazole Diffusion in Infected Human Brain

作者：Claire Rouzaud, Vincent Jullien, Anne Herbrecht, Bruno Palmier, Simona Lapusan, Marjolaine Morgand, Romain Guéry, Amélie Dureault, François Danion, Stéphanie Puget, Lauriane Goldwirt, Fanny Lanternier, Olivier Lortholary · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2019 · DOI：10.1128/aac.02474-18 · 被引用次数：37 · 研究领域：Antifungal resistance and susceptibility、Fungal Infections and Studies、Pneumocystis jirovecii pneumonia detection and treatment

We report the cases of a 39-year-old woman with chronic lymphocytic leukemia and a 21-year-old man with chronic granulomatous disease treated for cerebral aspergillosis. The patients required radical surgery for infection progression despite adequate isavuconazole plasma concentration or neurological complication. We thus decided to measure the brain isavuconazole concentration. These results suggest that the concentrations of isavuconazole obtained in the infected brain tissue clearly differ from those obtained in the normal brain tissue and the cerebrospinal fluid.