Roles of Neuropeptide Y in Neurodegenerative and Neuroimmune Diseases

作者：Chunrong Li, Xiujuan Wu, Shan Liu, Yue Zhao, Jie Zhu, Kangding Liu · 发表于：Frontiers in Neuroscience · 年份：2019 · DOI：10.3389/fnins.2019.00869 · 被引用次数：123 · 研究领域：Neuropeptides and Animal Physiology、Cardiovascular, Neuropeptides, and Oxidative Stress Research、Cancer, Stress, Anesthesia, and Immune Response

Neuropeptide Y (NPY) is a neurotransmitter or neuromodulator that mainly exists in the nervous system. It plays a neuroprotective role in organisms and widely participates in the regulation of various physiological processes in vivo. Studies in both humans and animal models have been revealed that NPY levels are altered in some neurodegenerative and neuroimmune disorders. NPY plays various roles in these diseases, such as exerting a neuroprotective effect, increasing trophic support, decreasing excitotoxicity, regulating calcium homeostasis, and attenuating neuroinflammation. In this review, we will focus on the roles of NPY in the pathological mechanisms of neurodegenerative and neuroimmune diseases, highlighting NPY as a potential therapeutic target in these diseases.