Novel serum metabolites associate with cognition phenotypes among Bogalusa Heart Study participants

作者：Mengyao Shi, Lydia Bazzano, Jiang He, Xiaoying Gu, Changwei Li, Shengxu Li, Kristine Yaffe, Jason M. Kinchen, Patrick Stuchlik, Xuenan Mi, Jovia L. Nierenberg, Alexander C. Razavi, Tanika N. Kelly · 发表于：Aging · 年份：2019 · DOI：10.18632/aging.102107 · 被引用次数：21 · 研究领域：Metabolomics and Mass Spectrometry Studies、Cancer-related cognitive impairment studies、Advanced Chemical Sensor Technologies

BACKGROUND: Metabolomics study provides an opportunity to identify novel molecular determinants of altered cognitive function. METHODS: During 2013 to 2016 Bogalusa Heart Study (BHS) visit, 1,177 participants underwent untargeted, ultrahigh performance liquid chromatography-tandem mass spectroscopy metabolomics profiling. Global cognition and five cognition domains were also assessed. The cross-sectional associations of single metabolites with cognition were tested using multiple linear regression models. Weighted correlation network analysis was used to examine the covariable-adjusted correlations of modules of co-abundant metabolites with cognition. Analyses were conducted in the overall sample and according to both ethnicity and sex. RESULTS: , respectively). CONCLUSION: The novel associations of 5 known metabolites and 2 metabolite modules with cognition provide insights into the physiological mechanisms regulating cognitive function.