Discovery of biomarkers for the presence and progression of left ventricular diastolic dysfunction and HEart faiLure with Preserved ejection Fraction in patients at risk for cardiovascular disease: rationale and design of the HELPFul case-cohort study in a Dutch cardiology outpatient clinic

作者：Gideon Valstar, Sophie H. Bots, Floor Groepenhoff, Aisha Gohar, Frans H. Rutten, Tim Leiner, Maarten J. Cramer, Arco J. Teske, Leonardo Paskah Suciadi, Roxana Menken, Gerard Pasterkamp, Folkert W. Asselbergs, Leonard Hofstra, Michael Bots, Hester M. den Ruijter · 发表于：BMJ Open · 年份：2019 · DOI：10.1136/bmjopen-2018-028408 · 被引用次数：18 · 研究领域：Cardiovascular Function and Risk Factors、Cardiac Imaging and Diagnostics、Cardiovascular Disease and Adiposity

INTRODUCTION: Left ventricular diastolic dysfunction (LVDD) is a common condition in both sexes that may deteriorate into heart failure (HF) with preserved ejection fraction (pEF), although this seems to happen more often in women than in men. Both LVDD and HFpEF often go unrecognised, necessitating the discovery of biomarkers that aid both the identification of individuals with LVDD at risk of developing HF and identification of individuals most likely to benefit from treatment. METHODS AND ANALYSIS: HELPFul is an ongoing case-cohort study at a Dutch cardiology outpatient clinic enrolling patients aged 45 years and older without history of cardiovascular disease, who were referred by the general practitioner for cardiac evaluation. We included a random sample of patients and enriched the cohort with cases (defined as an E/e' ≥8 measured with echocardiography). Information about medical history, cardiovascular risk factors, electrocardiography, echocardiography, exercise test performance, common carotid intima-media thickness measurement and standard cardiovascular biomarkers was obtained from the routine care data collected by the cardiology outpatient clinic. Study procedure consists of extensive venous blood collection for biobanking and additional standardised questionnaires. Follow-up will consist of standardised questionnaires by mail and linkage to regional and national registries. We will perform cardiac magnetic resonance imaging and coronary CT angiography in a subg...