Fluorescence Detection and Dissociation of Amyloid‐β Species for the Treatment of Alzheimer's Disease

作者：Guanglei Lv, Yang Shen, Wubin Zheng, Jiajia Yang, Chunxia Li, Jun Lin · 发表于：Advanced Therapeutics · 年份：2019 · DOI：10.1002/adtp.201900054 · 被引用次数：32 · 研究领域：Alzheimer's disease research and treatments、Cholinesterase and Neurodegenerative Diseases、Supramolecular Self-Assembly in Materials

Abstract Alzheimer's disease (AD) is one of the most prevalent forms of neurodegenerative disease. It is well established that the β‐amyloid peptide (Aβ) species existing in several forms, such as soluble monomers, oligomers, and insoluble aggregates, play an essential role in the pathophysiology of AD. Therefore, much effort has been made to specifically detect Aβ species and to inhibit Aβ aggregation for the treatment of AD. In this review, an overview of recent advances in detecting different Aβ forms mainly containing Aβ aggregates, Aβ oligomers, and Aβ protofibrils is provided. In addition, photodynamic therapy (PDT) and photothermal therapy (PTT) are considered to be promising modalities for the treatment of AD because of the minimal invasiveness and high spatial selectivity. Herein, the strategies of inhibiting Aβ aggregation and dissociating Aβ aggregates using PDT, PTT, and Aβ inhibitors for the treatment of AD are summarized.