Association of lipoprotein subfractions and glycoprotein acetylation with coronary plaque burden in SLE

作者：Monica Purmalek, Philip M. Carlucci, Amit K. Dey, Maureen Sampson, Yenealem Temesgen‐Oyelakin, Simantini Sakhardande, Joseph B Lerman, Alice Fike, Michael Davis, Jonathan H. Chung, Taufiq Salahuddin, Zerai Manna, Sarthak Gupta, Marcus Y. Chen, Sarfaraz Hasni, Nehal N. Mehta, Alan T. Remaley, Mariana J. Kaplan · 发表于：Lupus Science & Medicine · 年份：2019 · DOI：10.1136/lupus-2019-000332 · 被引用次数：27 · 研究领域：Advanced MRI Techniques and Applications、Diabetes, Cardiovascular Risks, and Lipoproteins、Cardiovascular Health and Disease Prevention

OBJECTIVE: Subjects with SLE display an enhanced risk of atherosclerotic cardiovascular disease (CVD) that is not explained by Framingham risk. This study sought to investigate the utility of nuclear MR (NMR) spectroscopy measurements of serum lipoprotein particle counts and size and glycoprotein acetylation (GlycA) burden to predict coronary atherosclerosis in SLE. METHODS: Coronary plaque burden was assessed in SLE subjects and healthy controls using coronary CT angiography. Lipoproteins and GlycA were quantified by NMR spectroscopy. RESULTS: SLE subjects displayed statistically significant decreases in high-density lipoprotein (HDL) particle counts and increased very low-density lipoprotein (VLDL) particle counts compared with controls. Non-calcified coronary plaque burden (NCB) negatively associated with HDL subsets whereas it positively associated with VLDL particle counts in multivariate adjusted models. GlycA was significantly increased in SLE sera compared with controls. In contrast to high-sensitivity C reactive protein, elevations in GlycA in SLE significantly associated with NCB and insulin resistance (IR), though the association with NCB was no longer significant after adjusting for prednisone use. CONCLUSIONS: Patients with SLE display a proatherogenic lipoprotein profile that may significantly contribute to the development of premature CVD. The results demonstrate that NMR measures of GlycA and lipoprotein profiles, beyond what is captured in routine clinical la...