Considerations in selecting postoperative analgesia for pregnant sheep following fetal instrumentation surgery

作者：Tamara J. Varcoe, Jack R. T. Darby, Kathryn L. Gatford, Stacey L. Holman, Pearl Cheung, Mary J. Berry, Michael D. Wiese, Janna L. Morrison · 发表于：Animal Frontiers · 年份：2019 · DOI：10.1093/af/vfz019 · 被引用次数：37 · 研究领域：Veterinary Pharmacology and Anesthesia、Enhanced Recovery After Surgery、Anesthesia and Pain Management

As a model of human pregnancy, research studies in catheterized fetal sheep have made significant contributions to our understanding of both normal and abnormal fetal development. Owing to the invasive nature of catheterization surgery, effective postoperative analgesia is required. Decisions regarding appropriate analgesia should consider effectiveness in reducing maternal pain and fetal well-being as well as potential impacts upon fetal physiological parameters under investigation. The reporting of analgesic regimes in all research studies should comply with the ARRIVE guidelines. Studies in sheep have made significant contributions to our understanding of normal and abnormal fetal development, and have enabled scientists and clinicians to answer questions about the etiology and treatment of poor maternal, placental, and fetal health (Morrison et al., 2018). One fundamental advantage of utilizing sheep as an animal model of human pregnancy is the ability to surgically implant a diverse range of physiological monitoring systems into both maternal and fetal compartments. Implanting indwelling catheters into the maternal and fetal vasculature (Meschia et al., 1965) enables repetitive materno-fetal blood sampling free from any confounding effects of maternal, and therefore fetal anesthesia. In addition, surgical manipulation of the ovine fetus has provided key foundational knowledge for novel in utero treatment options for conditions such as spina bifida and diaphragmatic herni...