Dynamic functional connectivity changes associated with dementia in Parkinson’s disease

作者：Eleonora Fiorenzato, Antonio P. Strafella, Jinhee Kim, Roberta Schifano, Luca Weis, Angelo Antonini, Roberta Biundo · 发表于：Brain · 年份：2019 · DOI：10.1093/brain/awz192 · 被引用次数：331 · 研究领域：Functional Brain Connectivity Studies、Advanced MRI Techniques and Applications、Advanced Neuroimaging Techniques and Applications

Dynamic functional connectivity captures temporal variations of functional connectivity during MRI acquisition and it may be a suitable method to detect cognitive changes in Parkinson's disease. In this study, we evaluated 118 patients with Parkinson's disease matched for age, sex and education with 35 healthy control subjects. Patients with Parkinson's disease were classified with normal cognition (n = 52), mild cognitive impairment (n = 46), and dementia (n = 20) based on an extensive neuropsychological evaluation. Resting state functional MRI and a sliding-window approach were used to study the dynamic functional connectivity. Dynamic analysis suggested two distinct connectivity 'States' across the entire group: a more frequent, segregated brain state characterized by the predominance of within-network connections, State I, and a less frequent, integrated state with strongly connected functional internetwork components, State II. In Parkinson's disease, State I occurred 13.89% more often than in healthy control subjects, paralleled by a proportional reduction of State II. Parkinson's disease subgroups analyses showed the segregated state occurred more frequently in Parkinson's disease dementia than in mild cognitive impairment and normal cognition groups. Further, patients with Parkinson's disease dementia dwelled significantly longer in the segregated State I, and showed a significant lower number of transitions to the strongly interconnected State II compared to the othe...