Validation of the Khorana score in acute myeloid leukemia patients: a single-institution experience

作者：Abu‐Sayeef Mirza, Seongseok Yun, Najla Al Ali, Hannah Shin, Joseph Luke O’Neil, Maher Elharake, Daniel P. Schwartz, Katherine Robinson, Ethan Nowell, Grace Engle, Ibraahim Badat, Thomas Brimer, Amra Kuc, Ashton Sequeira, Sabbir Mirza, Dhiraj Sikaria, Jesus Diaz Vera, Noah Hackney, Sammy Abusrur, Jose Jesurajan, Jameson Kuang, Shreyans Patel, Sabrina Khalil, Sonya Bhaskar, Alexander Beard, Toaa Abuelenen, Kevin Ratnasamy, Nathan Visweshwar, Rami S. Komrokji, Michael Jaglal · 发表于：Thrombosis Journal · 年份：2019 · DOI：10.1186/s12959-019-0202-z · 被引用次数：26 · 研究领域：Venous Thromboembolism Diagnosis and Management、Acute Myeloid Leukemia Research、Inflammatory Biomarkers in Disease Prognosis

Although patients with acute myeloid leukemia (AML) were shown to have an increased risk of thrombosis, no thrombosis risk assessment scoring system has been developed for AML patients. The Khorana Risk Score (KRS), which has been widely used for thrombosis risk assessment in the clinical setting, was developed on the basis of solid tumor data and has not been validated among AML patients. This study aims to validate the use of the KRS as a thrombosis risk-scoring system among patients with AML. Using data from H. Lee Moffitt Cancer Center and Research Institution’s Total Cancer Care Research Study, we retrospectively identified patients who were histologically confirmed with AML from 2000 to 2018. Clinical and laboratory variables at the time of AML diagnosis were characterized and analyzed. The thrombotic event rate was estimated with the Kaplan-Meier method and compared using the log-rank test. A total of 867 AML patients were included in the analysis. The median age at AML diagnosis was 75 years (range, 51–96), and the majority were male (65%, n = 565). A total of 22% ( n = 191), 51% ( n = 445), 24% ( n = 207), and 3% ( n = 24) of patients had a KRS of 0, 1, 2, and 3, respectively. A total of 42 thrombotic events (3% [ n = 6/191] with a KRS of 1; 5% [ n = 23/445] with a KRS of 2; 6.3% [ n = 13/207] with a KRS of 3) were observed, with a median follow-up of 3 months (range, 0.1–307). There was no statistical difference in the risk of thrombosis between these groups ( P = ....