The Pseudomonas stutzeri-Specific Regulatory Noncoding RNA NfiS Targets katB mRNA Encoding a Catalase Essential for Optimal Oxidative Resistance and Nitrogenase Activity

作者：Hongyang Zhang, Yuhua Zhan, Yongliang Yan, Yichao Liu, Guihua Hu, Shanshan Wang, Hua Yang, Xuemeng Qiu, Yaqun Liu, Li Jiang, Wei Lü, Claudine Elmerich, Min Lin · 发表于：Journal of Bacteriology · 年份：2019 · DOI：10.1128/jb.00334-19 · 被引用次数：33 · 研究领域：Microbial Fuel Cells and Bioremediation、Bacterial Genetics and Biotechnology、Genomics and Phylogenetic Studies

Protection against oxygen damage is crucial for survival of nitrogen-fixing bacteria due to the extreme oxygen sensitivity of nitrogenase. This work exemplifies how the small ncRNA NfiS coordinates oxidative stress response and nitrogen fixation via base pairing with katB mRNA and nifK mRNA. Hence, NfiS acts as a molecular link to coordinate the expression of genes involved in oxidative stress response and nitrogen fixation. Our study provides the first insight into the biological functions of NfiS in oxidative stress regulation and adds a new regulation level to the mechanisms that contribute to the oxygen protection of the MoFe nitrogenase.