Visible-Light-Induced Copper-Catalyzed Decarboxylative Coupling of Redox-Active Esters with N -Heteroarenes

作者：Xue‐Li Lyu, Shisheng Huang, Hongjian Song, Yuxiu Liu, Qingmin Wang · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.9b02105 · 被引用次数：80 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Sulfur-Based Synthesis Techniques

Herein we report a protocol for visible-light-induced copper-catalyzed decarboxylative coupling reactions between N -heteroarenes and redox-active esters. Various N -hydroxyphthalimide esters reacted with isoquinoline, quinoline, pyridine, pyrimidine, quinazoline, phthalazine, phenanthridine, and pyridazine to give the corresponding products in modest to excellent yields. The reactions proceed under mild conditions and have a broad scope and high functional group tolerance. Mechanistic studies revealed that the catalytic behavior of Cu I photocatalyst generated in situ was consistent with that of preformed [Cu(dmp)(xantphos)]BF 4 .