Visible-Light-Promoted Manganese-Catalyzed Atom Transfer Radical Cyclization of Unactivated Alkyl Iodides

作者：Wei‐Zhi Weng, Liang Hao, Run‐Zhou Liu, Yun‐Xing Ji, Bo Zhang · 发表于：Organic Letters · 年份：2019 · DOI：10.1021/acs.orglett.9b01918 · 被引用次数：57 · 研究领域：Radical Photochemical Reactions、Oxidative Organic Chemistry Reactions、Catalytic C–H Functionalization Methods

An expedient visible-light-promoted atom transfer radical cyclization (ATRC) reaction of unactivated alkyl iodides facilitated by earth-abundant and inexpensive manganese catalysis is described. The practical protocol shows a broad substrate scope and good functional-group tolerance, allowing for the preparation of synthetically valuable alkenyl iodides and diquinanes under simple and mild reaction conditions. Notably, the method provides a net redox-neutral strategy for ATRC reactions that avoids classic hydrogen atom transfer mechanism.