The ENCODE Blacklist: Identification of Problematic Regions of the Genome

作者：Haley M. Amemiya, Anshul Kundaje, Alan P. Boyle · 发表于：Scientific Reports · 年份：2019 · DOI：10.1038/s41598-019-45839-z · 被引用次数：2125 · 研究领域：Single-cell and spatial transcriptomics、Genomics and Phylogenetic Studies、Gene expression and cancer classification

Functional genomics assays based on high-throughput sequencing greatly expand our ability to understand the genome. Here, we define the ENCODE blacklist- a comprehensive set of regions in the human, mouse, worm, and fly genomes that have anomalous, unstructured, or high signal in next-generation sequencing experiments independent of cell line or experiment. The removal of the ENCODE blacklist is an essential quality measure when analyzing functional genomics data.