Western Diet-Fed, Aortic-Banded Ossabaw Swine

作者：T. Dylan Olver, Jenna C. Edwards, Thomas J. Jurrissen, Adam B. Veteto, J. Louise Jones, Chen Gao, Christoph Daniel Rau, Chad M. Warren, Paula J. Klutho, Linda Alex, Stephanie C. Ferreira-Nichols, Jan R Ivey, Pamela K. Thorne, Kerry S. McDonald, Maike Krenz, Christopher P. Baines, Ross John Solaro, Yibin Wang, David A. Ford, Timothy L. Domeier, Jaume Padilla, R. Scott Rector, Craig A. Emter · 发表于：JACC Basic to Translational Science · 年份：2019 · DOI：10.1016/j.jacbts.2019.02.004 · 被引用次数：74 · 研究领域：Cardiovascular Disease and Adiposity、Cardiovascular Conditions and Treatments、Cardiovascular Function and Risk Factors

The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population. This report provides evidence supporting the hypothesis that Western Diet-fed, aortic-banded Ossabaw swine display an integrated physiological, morphological, and genetic phenotype evocative of cardio-metabolic heart failure. This new preclinical animal model displays a distinctive constellation of findings that are conceivably useful to extending the understanding of how pre-existing cardio-metabolic syndrome can contribute to developing HF.