Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

作者：Jason M. Rohde, Kyle R. Brimacombe, Li Liu, Michael E. Pacold, Adam Yasgar, Dorian M. Cheff, Tobie D. Lee, Ganesha Rai, Bolormaa Baljinnyam, Zhuyin Li, Anton Simeonov, Matthew D. Hall, Min Shen, David M. Sabatini, Matthew B. Boxer · 发表于：Bioorganic & Medicinal Chemistry · 年份：2018 · DOI：10.1016/j.bmc.2018.02.016 · 被引用次数：47 · 研究领域：Amino Acid Enzymes and Metabolism、Cancer, Hypoxia, and Metabolism、Epigenetics and DNA Methylation