Variation of a major facilitator superfamily gene contributes to differential cadmium accumulation between rice subspecies

作者：Huili Yan, Wenxiu Xu, Jianyin Xie, Yiwei Gao, Lulu Wu, Liang Sun, Feng Lu, Xu Chen, Tian Zhang, Changhua Dai, Ting Li, Xiuni Lin, Zhanying Zhang, Xueqiang Wang, Fengmei Li, Xiaoyang Zhu, Jinjie Li, Zichao Li, Caiyan Chen, Mi Ma, Hongliang Zhang, Zhenyan He · 发表于：Nature Communications · 年份：2019 · DOI：10.1038/s41467-019-10544-y · 被引用次数：309 · 研究领域：Heavy metals in environment、Aluminum toxicity and tolerance in plants and animals、Plant Micronutrient Interactions and Effects

Abstract Cadmium (Cd) accumulation in rice grain poses a serious threat to human health. While several transport systems have been reported, the complexity of rice Cd transport and accumulation indicates the necessity of identifying additional genes, especially those that are responsible for Cd accumulation divergence between indica and japonica rice subspecies. Here, we show that a gene, OsCd1 , belonging to the major facilitator superfamily is involved in root Cd uptake and contributes to grain accumulation in rice. Natural variation in OsCd1 with a missense mutation Val449Asp is responsible for the divergence of rice grain Cd accumulation between indica and japonica . Near-isogenic line tests confirm that the indica variety carrying the japonica allele OsCd1 V449 can reduce the grain Cd accumulation. Thus, the japonica allele OsCd1 V449 may be useful for reducing grain Cd accumulation of indica rice cultivars through breeding.