Trimethylamine N -oxide–derived zwitterionic polymers: A new class of ultralow fouling bioinspired materials

作者：Bowen Li, Priyesh Jain, Jinrong Ma, Josh Smith, Zhefan Yuan, Hsiang‐Chieh Hung, Yuwei He, Xiaojie Lin, Kan Wu, Jim Pfaendtner, Shaoyi Jiang · 发表于：Science Advances · 年份：2019 · DOI：10.1126/sciadv.aaw9562 · 被引用次数：294 · 研究领域：Polymer Surface Interaction Studies、Marine Biology and Environmental Chemistry、Bone Tissue Engineering Materials

-oxide (TMAO), a zwitterionic osmolyte and the most effective protein stabilizer, we here report TMAO-derived zwitterionic polymers (PTMAO) as a new class of ultralow fouling biomaterials. The nonfouling properties of PTMAO were demonstrated under highly challenging conditions. The mechanism accounting for the extraordinary hydration of PTMAO was elucidated by molecular dynamics simulations. The discovery of PTMAO polymers demonstrates the power of molecular understanding in the design of new biomimetic materials and provides the biomaterials community with another class of nonfouling zwitterionic materials.