Amyloid β oligomers constrict human capillaries in Alzheimer’s disease via signaling to pericytes

作者：Ross Nortley, Nils Korte, Pablo Izquierdo, Chanawee Hirunpattarasilp, Anusha Mishra, Zane Jaunmuktane, Vasiliki Kyrargyri, Thomas Pfeiffer, Lila Khennouf, Christian Madry, Hui Gong, Angela Richard-Loendt, Wenhui Huang, Takashi Saito, Takaomi C. Saido, Sebastian Brandner, Huma Sethi, David Attwell · 发表于：Science · 年份：2019 · DOI：10.1126/science.aav9518 · 被引用次数：703 · 研究领域：Alzheimer's disease research and treatments、Barrier Structure and Function Studies、Neuroinflammation and Neurodegeneration Mechanisms

Pericytes put the squeeze on cognition Like a computer, the brain needs a reliable source of power, which is provided as oxygen and glucose in the blood. However, in many neurological disorders this energy supply is disrupted. Brain blood flow is controlled by adjustment of the diameters of the vessels supplying the blood. Nortley et al. found that, both in humans developing Alzheimer's disease (AD) and in a mouse model of AD, brain capillaries become squeezed by pericytes (see the Perspective by Liesz). By defining the underlying mechanism, they suggest potential targets for therapy in early AD. Science , this issue p. eaav9518 ; see also p. 223