Gut microbiota partially mediates the effects of fine particulate matter on type 2 diabetes: Evidence from a population-based epidemiological study

作者：Tao Liu, Xiaojiao Chen, Yanjun Xu, Wei Wu, Wenli Tang, Zihui Chen, Guiyuan Ji, Jiewen Peng, Qi Jiang, Jianpeng Xiao, Xing Li, Weilin Zeng, Xiaojun Xu, Jianxiong Hu, Yuming Guo, Fei Zou, Qingfeng Du, Hongwei Zhou, Yan He, Wenjun Ma · 发表于：Environment International · 年份：2019 · DOI：10.1016/j.envint.2019.05.076 · 被引用次数：141 · 研究领域：Gut microbiota and health、Immune responses and vaccinations、Oral microbiology and periodontitis research

Experimental studies have indicated that alterations in the gut microbiota might play a role in the pathway of diabetes induction resulting from particulate matter pollution with aerodynamic diameters < 2.5 μm (PM2.5). However, few human studies have examined such experimental findings. Here, we examine the mediating effects of gut microbial dysbiosis on the associations between PM2.5 and particulate matter pollution with aerodynamic diameters < 1 μm (PM1) on diabetes using the Guangdong Gut Microbiome Project (GGMP) dataset. A multistage cluster sampling method was employed to recruit adult participants from communities in Guangdong. Each participant was interviewed using a questionnaire, fasting blood and stool samples were collected, and the exposure to air pollutants was assessed using a spatiotemporal land-use regression model. The mediation analysis was conducted to estimate the associations among air pollutants, gut microbiota diversity and diabetes. Both PM2.5 and PM1 were positively associated with the risks of impaired fasting glucose (IFG) or type 2 diabetes and negatively associated with alpha diversity indices of the gut microbiota. The mediation analyses indicated that the associations of PM2.5 and PM1 with the risk of type 2 diabetes were partially mediated by the decrease in gut microbiota diversity. Moreover, we found that 79 (PM2.5 on IFG), 84 (PM2.5 on type 2 diabetes), 83 (PM1 on IFG) and 89 (PM1 on type 2 diabetes) bacterial taxa could partially mediate t...