A Novel and Facile synthesis of Pyrazolo [3,4- b ]Pyridines

作者：Wei Zhao, Zheng Ming Li, De Kai Yuan · 发表于：Journal of Chemical Research · 年份：2002 · DOI：10.3184/030823402103172635 · 被引用次数：9 · 研究领域：Synthesis of heterocyclic compounds、Synthesis and Characterization of Heterocyclic Compounds、Synthesis and biological activity

Pyrazolo[3,4- b]pyridines have been obtained by the condensation of 5-amino-4-cyanopyrazole, readily available by the reaction of dithioacetals with substituted hydrazines, with β-ketoesters or β-diketone in the presence of tin(IV) chloride at reflux temperature in dry toluene.