Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

作者：Annie N. Cowell, Eva S. Istvan, Amanda K. Lukens, Marı́a G. Gómez-Lorenzo, Manu Vanaerschot, Tomoyo Sakata‐Kato, Erika L. Flannery, Pamela Magistrado, Edward S. Owen, Matthew Abraham, Gregory LaMonte, Heather J. Painter, Roy M. Williams, Virginia Franco, María Linares, Ignacio Arriaga, Selina E. R. Bopp, Victoria C. Corey, Nina F. Gnädig, Olivia Coburn‐Flynn, Christin Reimer, Purva Gupta, James M. Murithi, Pedro A. Moura, Olivia Fuchs, Erika Sasaki, Sang Woon Kim, Christine H. Teng, Lawrence Wang, Aslı Akidil, Sophie H. Adjalley, Paul A. Willis, Dionicio R. Siegel, Olga Tanaseichuk, Zhong Hui Yang, Yingyao Zhou, Manuel Llinás, Sabine Ottilie, Francisco‐Javier Gamo, Lee M, Daniel E. Goldberg, David A. Fidock, Dyann F. Wirth, Elizabeth A. Winzeler · 发表于：Science · 年份：2018 · DOI：10.1126/science.aan4472 · 被引用次数：283 · 研究领域：Malaria Research and Control、Mosquito-borne diseases and control、vaccines and immunoinformatics approaches

Dissecting Plasmodium drug resistance Malaria is a deadly disease with no effective vaccine. Physicians thus depend on antimalarial drugs to save lives, but such compounds are often rendered ineffective when parasites evolve resistance. Cowell et al. systematically studied patterns of Plasmodium falciparum genome evolution by analyzing the sequences of clones that were resistant to diverse antimalarial compounds across the P. falciparum life cycle (see the Perspective by Carlton). The findings identify hitherto unrecognized drug targets and drug-resistance genes, as well as additional alleles in known drug-resistance genes. Science , this issue p. 191 ; see also p. 159