Small Nucleolar RNAs: Insight Into Their Function in Cancer

作者：Junnan Liang, Jingyuan Wen, Zhao Huang, Xiaoping Chen, Bixiang Zhang, Liang Chu · 发表于：Frontiers in Oncology · 年份：2019 · DOI：10.3389/fonc.2019.00587 · 被引用次数：295 · 研究领域：RNA modifications and cancer、RNA regulation and disease、Cancer-related molecular mechanisms research

SnoRNAs are a class of non-coding RNAs, and divided into two classes, C/D box snoRNAs and H/ACA box snoRNAs. The canonical function of C/D box and H/ACA box snoRNAs is 2’-O-ribose methylation and pseudouridylation of ribosomal RNAs, respectively. Emerging evidences demonstrated that snoRNAs were involved in various physiological and pathological cellular processes. Mutations and aberrant expression of snoRNAs were reported in the cell transformation, tumorigenesis and metastasis, indicating that snoRNAs may serve as biomarkers or therapeutic targets of cancer. Hence, it is meaningful to further study the functions and underlying mechanism of snoRNAs. In this review, we summarize the biogenesis and functions of snoRNAs, the association of snoRNAs in different types of cancers and their potential roles in cancer diagnosis and therapy.