Process Development of the Sharpless Catalytic Asymmetric Dihydroxylation Reaction To Prepare Methyl (2 R ,3 S )-2,3-Dihydroxy-3-phenylpropionate

作者：Xinbo Lu, Zhunle Xu, Guojun Yang · 发表于：Organic Process Research & Development · 年份：2000 · DOI：10.1021/op000035j · 被引用次数：32 · 研究领域：Analytical Chemistry and Chromatography、Oxidative Organic Chemistry Reactions、Molecular spectroscopy and chirality

A typical Sharpless catalytic asymmetric dihydroxylation (ADH) process to make methyl (2 R,3 S )-2,3-dihydroxy-3 phenylpropionate has been successfully developed. The ADH reaction was exothermic and complete in 2−3 h without affecting the optical purity and yield. The major impurity of methyl (2 R )-hydroxy-3-keto-phenylpropionate, which may seriously damage the quality of diol, has been identified and removed properly in the process.